Senior/Principal Scientist: Translational Biology
Thame Laboratories, Ruislip, Middlesex, UK
NovalGen is a biopharmaceutical company focused on developing breakthrough therapies for cancer. The Company is based in greater London in the United Kingdom
We are looking for an ambitious and highly motivated candidate to support the development of the Company’s next-generation immunotherapy platform that focuses on bispecific technology. NovalGen’s pipeline is broad, exploiting novel as well as clinically validated targets to create potentially ground-breaking therapeutics.
This is a full-time position and attracts a competitive salary together with other benefits, including a performance-based bonus.
As a Senior/Principal Scientist in translational biology, you will join a rapidly growing world-class team and will have the opportunity to play a part in shaping the growth of this exciting new biotechnology start-up. Your role will include planning, conducting and overseeing in-depth preclinical studies to understand the pharmacology and mechanism of action of leads; defining preclinical and clinical biomarker strategies; and providing scientific input to the discovery of lead molecules across multiple programmes. You will also be an active participant in the selection of new drug targets, helping to define the rationale for target pairings and designing experiments for early proof-of-concept studies. You will be creative and flexible, with effective time management skills and a can-do approach to challenges. You will be required to keep current with relevant scientific literature, present project results to internal and external parties, prepare reports and maintain accurate and detailed experimental records.
- PhD or industry equivalent level of experience in immunology, cell biology, pharmacology or related field with at least 5 years’ experience working in translational biology, preferably in an industrial setting
- Experience planning, executing and interpreting pharmacology studies on lead molecules
- Expertise in developing assays for characterising the functionality of antibodies in relevant preclinical models
- Experience with defining biomarker strategies applied to clinical programmes and toxicology models for preclinical programmes
- Translate biology insights into appropriate research assays to link mechanism of action
- to specific patient populations
- Strong working knowledge of therapeutic antibody drug discovery
- Experience in an external facing role interacting with collaborators and CROs would be an advantage
- Strong analytical and communication skills
- Line management experience would be advantageous
- Excellent publication record or named on patents
- Team player with ability to work independently